Antioxidant and Anti-inflammatory Responses of Pycnogenol, Hibiscus Flower Extract, and Niacin in Skin Epithelial Cells

May 31, 2023  |  Vol.9, No.5  |  PP. 611-620  | PDF

AUTHORS:

Jung Min Park, General Graduate School, Dankook University, Republic of Korea

Jae Eun Choi, General Graduate School, Dankook University, Republic of Korea

Young Ki Lee, College of Health & Welfare, Dankook University, Republic of Korea

Jae Kyung Kim, College of Health & Welfare, Dankook University, Republic of Korea

KEYWORDS:

Anti-inflammatory, IL-6, Hibiscus Flower Extract, Pycnogenol, Soothing

Abstract

Currently, much research is being conducted on the potential of natural materials. Although many studies use plants to treat disease, studies on the effects of natural ingredients as cosmetics on the skin are limited. This study aimed to evaluate the anti-inflammatory effects of pycnogenol (PG), hibiscus flower extract (HE), and niacin (NA) to determine whether they are safe and effective as a cosmetic material with a soothing effect on the skin Two concentrations (1 μg/mL and 10 μg/mL) of PG, HE, and NA were added to 1 × 10 4 cells/well of skin epithelial cells to determine cell viability (MTT), antioxidant capacity (DPPH) and interleukin-6(IL-6) was measured. The inflammatory response triggered by each material was compared using absorbance. Cell viability in two concentrations of material (1 μg/mL and 10 μg/mL) was 103 ± 0.03% and 102 ± 0.05% for PG, 98 ± 0.04% and 158 ± 0.07% for HE, and 72 ± 0.09% and 106 ± 0.17% for NA, respectively. DPPH results were 54 ± 0.01% and 82 ± 0.01% for PG, 45 ± 0.01% and 47 ± 0.01% for HE, and 48 ± 0.01% and 46% for NA. The results above show that natural substances such as PG, HE, and NA do not exhibit cytotoxicity. The IL-6 levels in those following material-free group treatments were 17.6 pg/mL, in those following PG treatments were 9.5 pg/mL and 3.9 pg/mL, and in those following HE treatments were 9 pg/mL and 4.1 pg/mL. IL-6 levels, which are involved in inflammation, were also reduced. Through this study, it was revealed that PG and HE, which are mainly used as raw materials for health functional foods aimed at improving diseases, are not toxic to cells and have the effect of lowering the concentration of IL-6 that causes inflammation. This means that PG and HE natural materials can be used as raw materials for cosmetics. In particular, since it can be expected to be effective for sensitive skin and skin troubles related to inflammation, it is judged that it can affect cosmeceutical cosmetics by using the functional effect of the ingredient.

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Citations:

APA:
Park, J. M., Choi, J. E., Lee, Y. K., Kim, J. K. (2023). Antioxidant and Anti-inflammatory Responses of Pycnogenol, Hibiscus Flower Extract, and Niacin in Skin Epithelial Cells. Asia-pacific Journal of Convergent Research Interchange (APJCRI), ISSN: 2508-9080 (Print); 2671-5325 (Online), KCTRS, 9(5), 611-620. doi: 10.47116/apjcri.2023.05.51.

MLA:
Park, Jung Min, et al. “Antioxidant and Anti-inflammatory Responses of Pycnogenol, Hibiscus Flower Extract, and Niacin in Skin Epithelial Cells.” Asia-pacific Journal of Convergent Research Interchange, ISSN: 2508-9080 (Print); 2671-5325 (Online), KCTRS, vol. 9, no. 5, 2023, pp. 611-620. APJCRI, http://apjcriweb.org/content/vol9no5/51.html.

IEEE:
[1] J. M. Park, J. E. Choi, Y. K. Lee, J. K. Kim, “Antioxidant and Anti-inflammatory Responses of Pycnogenol, Hibiscus Flower Extract, and Niacin in Skin Epithelial Cells.” Asia-pacific Journal of Convergent Research Interchange (APJCRI), ISSN: 2508-9080 (Print); 2671-5325 (Online), KCTRS, vol. 9, no. 5, pp. 611-620, May 2023.


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